Working PNM Classification and staging

PNM Classification: describing the anatomical extent of AE

based on the assessment of 3 components at the time of diagnosis.

P = HEPATIC LOCALIZATION

OF THE PARASITE

N = EXTRAHEPATIC INVOLVEMENT OF NEIGHBOURING ORGANS

 

M = ABSENCE OR PRESENCE OF DISTANT METASTASIS

P0=

No detectable tumor in the liver

[diaphragm, lung, pleura, pericardium, heart, gastric and duodenal wall, adrenal glands, peritoneum, retroperitoneum, parietal wall (muscles, skin, bone), pancreas, regional lymph nodes, liver ligaments]

(characterizing distant parasitic tumors: lung, distant lymph nodes, spleen, CNS, orbital, bone, muscles, skin, distant peritoneum and retroperitoneum)

P1=

Peripheral lesions without proximal vascular and/or biliary involvement

P2=

Central lesions with proximal vascular and/or biliary involvement of one lobe

 

X =

not evaluable

X =

not completely evaluated

P3=

Central lesions with hilar vascular and biliary involvement of both lobes and/or with involvement of two hepatic veins

 

0 =

no regional involvement

 

0 =

no metastasis

(negative chest-x-ray and negative cerebral CT)

P4=

Any liver lesion with extension along the vessels and the biliary tree

 

1 =

regional involvement of contiguous organs or tissue

 

1 =

metastasis

 

 

STAGING FOR PNM Classification

Stage I

P1

N0

M0

Stage II

P2

N0

M0

Stage IIIa

P3

N0

M0

Stage IIIb

P1-3

P4

N1

N0

M0

M0

Stage IV

P4

P1-4

N1

N0-1

M0

M1